Altered Goblet Cell Differentiation and Surface Mucus Properties in Hirschsprung Disease

Altered Goblet Cell Differentiation and Surface Mucus Properties in Hirschsprung Disease

Hirschsprung disease-associated enterocolitis (HAEC) leads to significant mortality and morbidity, but its pathogenesis remains unknown. Changes in the colonic epithelium related to goblet cells and the luminal mucus layer have been postulated to play a key role. Here we show that the colonic epithelium of both aganglionic and ganglionic segments are altered in patients and in mice with Hirschs...

Mucus Properties and Goblet Cell Quantification in Mouse, Rat and Human Ileal Peyer's Patches

Peyer's patches (PPs) are collections of lymphoid follicles in the small intestine, responsible for scanning the intestinal content for foreign antigens such as soluble molecules, particulate matter as well as intact bacteria and viruses. The immune cells of the patch are separated from the intestinal lumen by a single layer of epithelial cells, the follicle-associated epithelium (FAE). This ep...

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

Various acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and excess mucus production are central to the pathogenesis of chronic pulmonary diseases. However, little is known about the transcriptional programs that regulate goblet cell differentiation. Here, we show that SAM-pointed domain-containing Ets...

Altered Th1 Cell Differentiation

Altered mucus production and composition

Altered mucus production and composition 5 6 7 8 9 Melinda A. Engevik 1 , Mary Beth Yacyshyn 3 , Kristen A. Engevik 1 10 Jiang Wang 4 , Benjamin Darien 5 , Daniel J. Hassett 2 11 Bruce R. Yacyshyn 3,6 , Roger T. Worrell 1,6 12 13 14 Department of Molecular and Cellular Physiology 15 Department of Molecular Genetics, Biochemistry and Microbiology 16 Department of Medicine Division of Digestive D...